CD133+ hepatic stellate cells are progenitor cells

Hepatic stellate cells contribute to progenitor cells and liver regeneration.

Retinoid-storing hepatic stellate cells (HSCs) have recently been described as a liver-resident mesenchymal stem cell (MSC) population; however, it is not clear whether these cells contribute to liver regeneration or serve as a progenitor cell population with hepatobiliary characteristics. Here, we purified HSCs with retinoid-dependent fluorescence-activated cell sorting from eGFP-expressing ra...

characterization of megakaryocyte progenitor cells differentiated from umbilical cord blood cd133+ and cd133– cells

objective: this study was performed to determine the immunophenotype of megakaryocyte progenitor cells differentiated from ucb cd133+ and cd133− cells under the effects of interleukin–3 (il–3), interleukin–6 (il–6), stem cell factor (scf) and thrombopoietin (tpo) in vitro. materials and methods: cd133+and cd133− cells were isolated by using cd133 isolation kit following the manufacturer’s instr...

Hepatic Stellate Cells Preferentially Induce

Adult Hepatic Progenitor Cells

Human fetal hepatic progenitor cells are distinct from, but closely related to, hematopoietic stem/progenitor cells.

Much controversy surrounds the identity and origin of human hepatic stem and progenitor cells in part because of a lack of small animal models in which the developmental potential of isolated candidate cell populations can be functionally evaluated. We show here that adoptive transfer of CD34(+) cells from human fetal liver into sublethally irradiated NOD-SCID Il2rg(-/-) (NSG) mice leads to an ...